Metabolic rescue ameliorates mitochondrial encephalo‐cardiomyopathy in murine and human iPSC models of Leigh syndrome-Reference-Cited by-同舟云学术

Metabolic rescue ameliorates mitochondrial encephalo‐cardiomyopathy in murine and human iPSC models of Leigh syndrome

Published:2022-07 Issue:7 Volume:12 Page:
ISSN:2001-1326
Container-title:Clinical and Translational Medicine
language:en
Short-container-title:Clinical & Translational Med

Author:

Yoon Jin‐Young¹²^ORCID,Daneshgar Nastaran³,Chu Yi³,Chen Biyi¹²,Hefti Marco³,Vikram Ajit¹^ORCID,Irani Kaikobad¹²,Song Long‐Sheng¹²,Brenner Charles⁴,Abel E. Dale⁵,London Barry¹²,Dai Dao‐Fu³

Affiliation:

1. Division of Cardiovascular Medicine, Department of Internal Medicine University of Iowa Carver College of Medicine Iowa City Iowa USA

2. Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine Iowa City Iowa USA

3. Department of Pathology, Carver College of Medicine University of Iowa Iowa City Iowa USA

4. Department of Diabetes & Cancer Metabolism City of Hope National Medical Center Duarte California USA

5. Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Department of Internal Medicine University of Iowa Carver College of Medicine, University of Iowa Iowa City Iowa USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Molecular Medicine,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ctm2.954

Reference48 articles.

1. Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome

2. Management of Leigh syndrome: Current status and new insights

3. Complex I Deficiency Due to Selective Loss of Ndufs4 in the Mouse Heart Results in Severe Hypertrophic Cardiomyopathy