Physiologically Based Precision Dosing Approach for Drug‐Drug‐Gene Interactions: A Simvastatin Network Analysis

Author:

Wojtyniak Jan‐Georg12ORCID,Selzer Dominik1,Schwab Matthias234,Lehr Thorsten1ORCID

Affiliation:

1. Clinical Pharmacy Saarland University Saarbrücken Germany

2. Dr. Margarete Fischer‐Bosch‐Institute of Clinical Pharmacology Stuttgart Germany

3. Departments of Clinical Pharmacology and Pharmacy and Biochemistry University of Tübingen Tübingen Germany

4. Cluster of Excellence iFIT (EXC2180) "Image‐guided and Functionally Instructed Tumor Therapies" University of Tübingen Tübingen Germany

Funder

Robert Bosch

European Commission

Horizon 2020 Framework Programme

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference56 articles.

1. Elsevier.Elsevier joins forces with pharmaceutical industry leaders to build new drug‐drug interaction risk calculator (2019). Accessed July 12 2020.

2. US Food and Drug Administration.Preventable adverse drug reactions: a focus on drug interactions (2018). Accessed July 12 2020.

3. Carr T.Too many meds? America’s love affair with prescription medication (2017). Accessed July 12 2020.

4. Drug–drug–gene interactions and adverse drug reactions

5. How common are drug and gene interactions? Prevalence in a sample of 1143 patients with CYP2C9, CYP2C19 and CYP2D6 genotyping

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