Affiliation:
1. Genelex Corporation, 3101 Western Avenue #100, Seattle, WA 98121, USA
Abstract
Aim: Drug–drug interactions (DDIs) are a widely recognized major cause of adverse drug reactions, but two other newly described important types of interactions also exist: drug–gene interactions (DGIs) and drug–drug–gene interactions (DDGIs). A drug–gene interaction occurs when a patient’s genetic CYP450 type (e.g., CYP2D6 poor metabolizer) affects that patient’s ability to clear a drug. A drug–drug–gene interaction occurs when the patient’s CYP450 genotype and another drug in the patient’s regimen (e.g., a CYP2D6 inhibitor) affect that individual’s ability to clear a drug. Their prevalence has not been previously described. This pilot study investigates the frequency of DDIs, DGIs and DDGIs in a sample of CYP450 tested individuals. Materials & methods: The investigators conducted a retrospective analysis of 1143 individuals with known CYP2D6, CYP2C19 and CYP2C9 genotypes. Using the individuals’ medication lists and YouScript®, a software tool to analyze cumulative DDIs and DGIs, the prevalence of DDI, DGI and DDGIs was analyzed. Results: A total of 1053 potential major or substantial interactions were identified in 501 individuals. DDIs accounted for 66.1% of the total interactions. The remaining 33.9% of interactions were DGIs (14.7%) and DDGIs (19.2%). When compared with DDIs alone, DGIs and DDGIs increased the total number of potentially clinically significant interactions by 51.3%. Conclusion: In the future, identifying DGIs and DDGIs may lead to a more comprehensive method of identifying individuals who are at risk for adverse drug reactions. Original submitted 3 May 2013; Revision submitted 6 January 2014
Subject
Pharmacology,Genetics,Molecular Medicine
Reference37 articles.
1. FDA. Safe use initiative: collaborating to reduce preventable harm from medications (2009).www.fda.gov/downloads/drugs/drugsafety/ucm188961.pdf
2. Centers for Disease Control and Prevention: Medication Safety Programme (2010).www.cdc.gov/medicationsafety/basics.html
3. Incidence of Adverse Drug Reactions in Hospitalized Patients
4. When good drugs go bad
Cited by
85 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献