Allosteric targeting of the FFA2 receptor (GPR43) restores responsiveness of desensitized human neutrophils-Reference-Cited by-同舟云学术

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Allosteric targeting of the FFA2 receptor (GPR43) restores responsiveness of desensitized human neutrophils

Published:2020-08-17 Issue:4 Volume:109 Page:741-751
ISSN:0741-5400
Container-title:Journal of Leukocyte Biology
language:en
Short-container-title:J Leukoc Biol

Author:

Frei Robert¹,Nordlohne Johannes²,Hüser Ulrike²,Hild Seda³,Schmidt Johannes³,Eitner Frank²,Grundmann Manuel³²^ORCID

Affiliation:

1. Institute of Experimental and Clinical Pharmacology Medical University of Graz Graz Austria

2. Bayer AG, Pharmaceuticals R&D, Preclinical Research Pharma Research Center Wuppertal Germany

3. Molecular, Cellular and Pharmacobiology Section Institute of Pharmaceutical Biology University of Bonn Bonn Germany

Publisher

Wiley

Subject

Cell Biology,Immunology,Immunology and Allergy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/JLB.2A0720-432R

Reference44 articles.

1. The Balancing Act of Neutrophils

2. Diverse novel functions of neutrophils in immunity, inflammation, and beyond

3. Neutrophil dysregulation during sepsis: an overview and update

4. Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways

5. Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation

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2. The neutrophil dynamic mass redistribution assay as a medium throughput primary cell screening assay;Journal of Pharmacology and Experimental Therapeutics;2023-10-20

3. An increase in the cytosolic concentration of free calcium ions activates the neutrophil NADPH-oxidase provided that the free fatty acid receptor 2 has been allosterically modulated;Cellular Signalling;2023-07

4. GPR43 stimulation on TCRαβ+ intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity;Journal of Neuroinflammation;2023-06-01

5. Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists;Journal of Medicinal Chemistry;2023-05-02

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