Development of a Disease Progression Model for Leucine‐Rich Repeat Kinase 2 in Parkinson's Disease to Inform Clinical Trial Designs

Author:

Ahamadi Malidi1,Conrado Daniela J2,Macha Sreeraj1,Sinha Vikram1,Stone Julie1,Burton Jackson2,Nicholas Timothy3,Gallagher Jill4,Dexter David4,Bani Massimo5,Boroojerdi Babak5,Smit Hans5,Weidemann Jonas6,Chen Chao7,Yang Minhua8,Maciuca Romeo9,Lawson Rachael10,Burn David10,Marek Kenneth11,Venuto Charles12,Stafford Bob2,Akalu Mussie2,Stephenson Diane2,Romero Klaus2,

Affiliation:

1. Merck & Co., Inc. Kenilworth New Jersey USA

2. Critical Path Institute Tucson Arizona USA

3. Pfizer Groton Connecticut USA

4. Parkinson's UK London UK

5. UCB Brussels Belgium

6. Lundbeck Copenhagen Denmark

7. GSK UK Uxbridge UK

8. Biogen Cambridge Massachusetts USA

9. Denali Therapeutics Inc. San Francisco California USA

10. Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation in Parkinson's Disease Newcastle University Newcastle upon Tyne UK

11. Institute of Neurodegenerative Diseases New Haven Connecticut USA

12. University of Rochester Rochester New York USA

Funder

Michael J. Fox Foundation for Parkinson's Research

AbbVie

Biogen

GE Healthcare

Genentech

GlaxoSmithKline

Eli Lilly and Company

Meso Scale Diagnostics

Pfizer

Roche

Sanofi Genzyme

Servier

UCB

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

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