Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project-Reference-Cited by-同舟云学术

Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project

Published:2023-12-22 Issue: Volume: Page:
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Su Yi¹,Protas Hillary¹,Luo Ji¹,Chen Kewei¹,Alosco Michael L.²,Adler Charles H.³,Balcer Laura J.⁴⁵,Bernick Charles⁶⁷,Au Rhoda²⁸⁹,Banks Sarah J.¹⁰,Barr William B.⁴,Coleman Michael J.¹¹,Dodick David W.³,Katz Douglas I.²¹²,Marek Kenneth L.¹³,McClean Michael D.¹⁴,McKee Ann C.²¹⁵,Mez Jesse²⁸,Daneshvar Daniel H.¹⁶,Palmisano Joseph N.¹⁷,Peskind Elaine R.¹⁸,Turner Robert W.¹⁹,Wethe Jennifer V.²⁰,Rabinovici Gil²¹,Johnson Keith²²,Tripodis Yorghos²²³,Cummings Jeffrey L.²⁴,Shenton Martha E.¹¹,Stern Robert A.²,Reiman Eric M.¹²⁵,

Affiliation:

1. Banner Alzheimer's Institute and Arizona Alzheimer's Consortium Phoenix Arizona USA

2. Department of Neurology Boston University Alzheimer's Disease Research Center Boston University CTE Center Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA

3. Department of Neurology Mayo Clinic College of Medicine, Mayo Clinic Arizona Scottsdale Arizona USA

4. Departments of Neurology NYU Grossman School of Medicine New York New York USA

5. Department of Population Health and Ophthalmology NYU Grossman School of Medicine New York New York USA

6. Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas Nevada USA

7. Department of Neurology University of Washington Seattle Washington USA

8. Framingham Heart Study Framingham Massachusetts USA

9. Slone Epidemiology Center; Departments of Anatomy & Neurobiology, Neurology, and Medicine Department of Epidemiology Boston University Chobanian & Avedisian School of Medicine; Boston University School of Public Health Boston Massachusetts USA

10. Departments of Neuroscience and Psychiatry University of California San Diego California USA

11. Departments of Psychiatry and Radiology Psychiatry Neuroimaging Laboratory Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA

12. Encompass Health Braintree Rehabilitation Hospital Braintree Massachusetts USA

13. Institute for Neurodegenerative Disorders, Invicro, LLC New Haven Connecticut USA

14. Department of Environmental Health Boston University School of Public Health Boston Massachusetts USA

15. VA Boston Healthcare System Boston Massachusetts USA

16. Department of Physical Medicine & Rehabilitation Massachusetts General Hospital, Spaulding Rehabilitation Hospital, Harvard Medical School Charlestown Massachusetts USA

17. Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Biostatistics and Epidemiology Data Analytics Center (BEDAC), Boston University School of Public Health Boston Massachusetts USA

18. Department of Psychiatry and Behavioral Sciences VA Northwest Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System; University of Washington School of Medicine Seattle Washington USA

19. Department of Clinical Research & Leadership The George Washington University School of Medicine & Health Sciences Washington District of Columbia USA

20. Department of Psychiatry and Psychology Mayo Clinic School of Medicine, Mayo Clinic Arizona Scottsdale Arizona USA

21. Department of Neurology University of California San Francisco San Francisco California USA

22. Gordon Center for Medical Imaging, Mass General Research Institute, Harvard Medical School Boston Massachusetts USA

23. Department of Biostatistics Boston University School of Public Health Boston Massachusetts USA

24. Department of Brain Health Chambers‐Grundy Center for Transformative Neuroscience School of Integrated Health Sciences, University of Nevada Las Vegas Las Vegas Nevada USA

25. University of Arizona, Arizona State University, Translational Genomics Research Institute Phoenix Arizona USA

Abstract

AbstractINTRODUCTIONTau is a key pathology in chronic traumatic encephalopathy (CTE). Here, we report our findings in tau positron emission tomography (PET) measurements from the DIAGNOSE CTE Research Project.METHODWe compare flortaucipir PET measures from 104 former professional players (PRO), 58 former college football players (COL), and 56 same‐age men without exposure to repetitive head impacts (RHI) or traumatic brain injury (unexposed [UE]); characterize their associations with RHI exposure; and compare players who did or did not meet diagnostic criteria for traumatic encephalopathy syndrome (TES).RESULTSSignificantly elevated flortaucipir uptake was observed in former football players (PRO+COL) in prespecified regions (p < 0.05). Association between regional flortaucipir uptake and estimated cumulative head impact exposure was only observed in the superior frontal region in former players over 60 years old. Flortaucipir PET was not able to differentiate TES groups.DISCUSSIONAdditional studies are needed to further understand tau pathology in CTE and other individuals with a history of RHI.

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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