Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model

Author:

Goldstein Lee E.1234,Fisher Andrew M.14,Tagge Chad A.14,Zhang Xiao-Lei5,Velisek Libor5,Sullivan John A.5,Upreti Chirag5,Kracht Jonathan M.4,Ericsson Maria6,Wojnarowicz Mark W.1,Goletiani Cezar J.5,Maglakelidze Giorgi M.5,Casey Noel13,Moncaster Juliet A.13,Minaeva Olga134,Moir Robert D.7,Nowinski Christopher J.8,Stern Robert A.28,Cantu Robert C.89,Geiling James10,Blusztajn Jan K.2,Wolozin Benjamin L.2,Ikezu Tsuneya2,Stein Thor D.211,Budson Andrew E.211,Kowall Neil W.211,Chargin David12,Sharon Andre412,Saman Sudad13,Hall Garth F.13,Moss William C.14,Cleveland Robin O.15,Tanzi Rudolph E.7,Stanton Patric K.5,McKee Ann C.2811

Affiliation:

1. Molecular Aging and Development Laboratory, Boston University School of Medicine, Boston, MA 02118, USA.

2. Boston University Alzheimer’s Disease Center, Boston, MA 02118, USA.

3. Boston University Photonics Center, Boston University, Boston, MA 02215, USA.

4. College of Engineering, Boston University, Boston, MA 02215, USA.

5. Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA.

6. Electron Microscope Facility, Harvard Medical School, Boston, MA 02115, USA.

7. Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA.

8. Center for Study of Traumatic Encephalopathy, Boston University School of Medicine, Boston, MA 02118, USA.

9. Department of Neurosurgery, Emerson Hospital, Concord, MA 01742, USA.

10. Department of Medicine, Veterans Affairs Medical Center, White River Junction, VT 05009, USA.

11. Neurology Service, Veterans Affairs Boston Healthcare System, Boston, MA 02130, USA.

12. Fraunhofer Center for Manufacturing Innovation at Boston University, Brookline, MA 02446, USA.

13. Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA.

14. Lawrence Livermore National Laboratory, Livermore, CA 94551, USA.

15. Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

Abstract

Blast exposure is associated with chronic traumatic encephalopathy, impaired neuronal function, and persistent cognitive deficits in blast-exposed military veterans and experimental animals.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference86 articles.

1. TRITON Report (Allen-Vanguard Threat Solutions Shrivenham UK 2011).

2. Mild Traumatic Brain Injury in U.S. Soldiers Returning from Iraq

3. Blast injuries

4. Independent Panel on the Safety and Security of United Nations Personnel in Iraq http://www.un.org/News/dh/iraq/safety-security-un-personnel-iraq.pdf [accessed 24 February 2012].

5. Blast-Related Traumatic Brain Injury: What Is Known?

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