High‐throughput automated scoring of Ki67 in breast cancer tissue microarrays from the Breast Cancer Association Consortium

Author:

Abubakar Mustapha1,Howat William J2,Daley Frances3,Zabaglo Lila4,McDuffus Leigh‐Anne2,Blows Fiona5,Coulson Penny1,Raza Ali H2,Benitez Javier67,Milne Roger89,Brenner Herman101112,Stegmaier Christa13,Mannermaa Arto1415,Chang‐Claude Jenny1617,Rudolph Anja16,Sinn Peter18,Couch Fergus J19,Tollenaar Rob A.E.M.20,Devilee Peter21,Figueroa Jonine22,Sherman Mark E23,Lissowska Jolanta24,Hewitt Stephen25,Eccles Diana26,Hooning Maartje J27,Hollestelle Antoinette27,WM Martens John27,HM van Deurzen Carolien28,Investigators kConFab29,Bolla Manjeet K30,Wang Qin30,Jones Michael1,Schoemaker Minouk1,Broeks Annegien31,van Leeuwen Flora E32,Van't Veer Laura31,Swerdlow Anthony J133,Orr Nick3,Dowsett Mitch34,Easton Douglas530,Schmidt Marjanka K3132,Pharoah Paul D530,Garcia‐Closas Montserrat23

Affiliation:

1. Division of Genetics and EpidemiologyThe Institute of Cancer ResearchLondon UK

2. Cancer Research UK Cambridge Institute, University of CambridgeCambridge UK

3. Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer ResearchLondon UK

4. Academic Department of Biochemistry, Royal Marsden HospitalFulham Road London

5. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of CambridgeCambridge UK

6. Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)Madrid Spain

7. Centro de Investigacion en Red de Enfermedades Raras (CIBERER)Valencia Spain

8. Cancer Epidemiology Centre, Cancer Council VictoriaMelbourne Australia

9. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of MelbourneMelbourne Australia

10. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)Heidelberg Germany

11. Division of Preventive Oncology, German Cancer Research Center (DKFZ), and National Center for Tumor Diseases (NCT)Heidelberg Germany

12. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)Heidelberg Germany

13. Saarland Cancer RegistrySaarland Germany

14. School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Cancer Center of Eastern Finland, University of Eastern FinlandKuopio Finland

15. Imaging Center, Department of Clinical Pathology, Kuopio University HospitalKuopio Finland

16. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)Heidelberg Germany

17. University Cancer Center Hamburg (UCCH), University Medical Center Hamburg‐EppendorfHamburg Germany

18. Department of PathologyInstitute of Pathology, Heidelberg University Hospital Germany

19. Department of Laboratory Medicine and PathologyMayo ClinicRochester, MN USA

20. Department of SurgeryLeiden University Medical Center The Netherlands

21. Department of Human Genetics & Department of PathologyLeiden University Medical CenterLeiden The Netherlands

22. Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh Scotland UK

23. Division of Cancer Epidemiology and GeneticsNational Cancer InstituteRockville Maryland USA

24. Department of Cancer Epidemiology and PreventionM. Sklodowska‐Curie Memorial Cancer Center and Institute of OncologyWarsaw Poland

25. Laboratory of PathologyNational Cancer Institute, National Institutes of HealthRockville MD USA

26. Faculty of Medicine Academic Unit of Cancer SciencesSouthampton General HospitalSouthampton UK

27. Family Cancer Clinic, Department of Medical Oncology, Erasmus MC Cancer InstituteRotterdam The Netherlands

28. Department of PathologyErasmus MC Cancer InstituteRotterdam The Netherlands

29. Department of GeneticsQIMR Berghofer Medical Research InstituteBrisbane Australia

30. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of CambridgeCambridge UK

31. Division of Molecular PathologyNetherlands Cancer Institute, Antoni van Leeuwenhoek HospitalAmsterdam The Netherlands

32. Division of Psychosocial Research and EpidemiologyNetherlands Cancer Institute, Antoni van Leeuwenhoek HospitalAmsterdam The Netherlands

33. Division of Breast Cancer ResearchThe Institute of Cancer ResearchLondon UK

Funder

Dutch Cancer Society

Dutch government

Dutch National Genomics Initiative

Genome Spain Foundation

Red Temática de Investigación Cooperativa en Cáncer

Asociación Española Contra el Cáncer and the Fondo de Investigación Sanitario

Instituto de Salud Carlos III

Baden Württemberg Ministry of Science, Research and Arts

German Cancer Aid (Deutsche Krebshilfe)

Kuopio University Hospital grants, Cancer Fund of North Savo, the Finnish Cancer Organizations, the Academy of Finland

University of Eastern Finland

National Breast Cancer Foundation

National Health and Medical Research Council (NHMRC)

Deutsche Krebshilfe e.V.

Hamburg Cancer Society

German Cancer Research Center (DKFZ)

Federal Ministry of Education and Research (BMBF) Germany

Specialized Program of Research Excellence (SPORE) in Breast Cancer

Breast Cancer Research Foundation

Mayo Clinic Breast Cancer Registry

Biobanking and Biomolecular Resources Research Infrastructure

National Cancer Institute, Department of Health and Human Services, USA

Cancer Research UK

UK National Institute for Health Research Biomedical Research Centre at the University of Cambridge

European Community's Seventh Framework Programme

Institute of Cancer Research (ICR)

NIHR Biomedical Research Centre

Breakthrough Breast Cancer, UK

Cancer Research, UK

Publisher

Wiley

Subject

Pathology and Forensic Medicine

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