1. Department of Pharmacology Faculty of Medicine University of Helsinki Helsinki Finland
2. Individualized Drug Therapy Research Program Faculty of Medicine University of Helsinki Helsinki Finland
3. Department of Clinical Pharmacology Faculty of Medicine University of Helsinki Helsinki University Hospital Finland
4. Department of Anaesthesiology, Intensive Care Medicine, and Pain Medicine University of Helsinki Helsinki University Hospital Helsinki Finland
5. Center for Translational Neuromedicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark