Neighbor-directed histidine N (τ)-alkylation: A route to imidazolium-containing phosphopeptide macrocycles-Reference-Cited by-同舟云学术

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Neighbor-directed histidine N (τ)-alkylation: A route to imidazolium-containing phosphopeptide macrocycles

Published:2015-11 Issue:6 Volume:104 Page:663-673
ISSN:0006-3525
Container-title:Biopolymers
language:en
Short-container-title:Biopolymers

Author:

Qian Wen-Jian¹,Park Jung-Eun²,Grant Robert³,Lai Christopher C.¹,Kelley James A.¹,Yaffe Michael B.³,Lee Kyung S.²,Burke Terrence R.¹

Affiliation:

1. Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick; Frederick MD 21702

2. Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda MD 20892

3. Department of Biology and Biological Engineering; Center for Cancer Research, Massachusetts Institute of Technology; Cambridge MA 02139

Funder

National Cancer Institute

National Institutes of Health

U.S. Department of Energy

Publisher

Wiley

Subject

Organic Chemistry,Biomaterials,Biochemistry,General Medicine,Biophysics

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/bip.22698/fullpdf

Reference40 articles.

1. Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells

2. Mitsunobu mischief: neighbor-directed histidine N(τ)-alkylation provides access to peptides containing selectively functionalized imidazolium heterocycles

3. Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

4. Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

5. Understanding the cellular uptake of phosphopeptides

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3. Divergent polo boxes in KKT2 and KKT3 initiate the kinetochore assembly cascade inTrypanosoma brucei;2022-06-02

4. Recent Advances in Macrocyclic Drugs and Microwave-Assisted and/or Solid-Supported Synthesis of Macrocycles;Molecules;2022-02-02

5. Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles;Organic & Biomolecular Chemistry;2021

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