Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles-Reference-Cited by-同舟云学术

Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles

Published:2021 Issue:36 Volume:19 Page:7843-7854
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hymel David¹,Tsuji Kohei¹^ORCID,Grant Robert A.²^ORCID,Chingle Ramesh M.¹,Kunciw Dominique L.¹,Yaffe Michael B.²^ORCID,Burke Terrence R.¹^ORCID

Affiliation:

1. Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA

2. Department of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

Abstract

A novel macrocyclic peptide strategy utilizing a glutamic acid analog that can work as an alkylated histidine replacement.

Funder

U.S. Department of Energy

National Cancer Institute

Japan Society for the Promotion of Science

National Institute of General Medical Sciences

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01120K

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