Online integrity monitoring in the Protein A step of mAb Production Processes-increasing reliability and process robustness

Author:

Bork Christopher1,Holdridge Sarah2,Walter Mark2,Fallon Eric1,Pohlscheidt Michael2

Affiliation:

1. Science and Engineering; Genentech Inc.; 1 Antibody Way Oceanside CA 92056

2. Manufacturing Operations; Genentech Inc.; 1 Antibody Way Oceanside CA 92056

Publisher

Wiley

Subject

Biotechnology

Reference25 articles.

1. Monoclonal antibodies in the clinic;Reichert;Nat Biotechnol,2001

2. Therapeutic monoclonal antibodies. Trends in development and approval in the US;Reichert;Curr Opin Mol Ther,2002

3. Monoclonal antibodies market;Reichert;Nat Rev Drug Discov,2004

4. Special report: blockbuster then and now-trends for billion-dollar drugs;Drapeau;Spect Ther Markets Emerg Technol,2007

5. Lessons from 60 years of pharmaceutical innovation;Munos;Nat Rev,2009

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