Dementia risk reduction: why haven't the pharmacological risk reduction trials worked? An in‐depth exploration of seven established risk factors

Author:

Peters Ruth12,Breitner John3,James Sarah4,Jicha Gregory A.5,Meyer Pierre‐Francois6,Richards Marcus4,Smith A. David7,Yassine Hussein N.8,Abner Erin5,Hainsworth Atticus H.910,Kehoe Patrick G.11,Beckett Nigel12,Weber Christopher13,Anderson Craig14,Anstey Kaarin J.12,Dodge Hiroko H.15

Affiliation:

1. Neuroscience Research Sydney New South Wales Australia

2. Department of Psychology University of New South Wales Sydney New South Wales Australia

3. Douglas Hospital Research Center and McGill University Quebec Canada

4. MRC Unit for Lifelong Health and Ageing at UCL University College London London UK

5. University of Kentucky Lexington Kentucky USA

6. Center for Studies on the Prevention of Alzheimer's Disease (PREVENT‐AD) Verdun Quebec Canada

7. OPTIMA Department of Pharmacology University of Oxford Oxford UK

8. Departments of Medicine and Neurology University of Southern California California USA

9. Molecular and Clinical Sciences Research Institute St Georges University of London London UK

10. Department of Neurology St George's Hospital London UK

11. Bristol Medical School University of Bristol Bristol UK

12. Guys and St Thomas’ NHS Foundation Trust London UK

13. Alzheimer's Association Chicago Illinois

14. The George Institute for Global Health Sydney New South Wales Australia

15. Oregon Health & Science University Portland Oregon USA

Publisher

Wiley

Subject

Psychiatry and Mental health,Neurology (clinical)

Reference196 articles.

1. Meta‐analysis of modifiable risk factors for Alzheimer's disease;Xu W;J Neurol Neurosurg Psychiatry,2015

2. PrinceM AlbaneseE GuerchetM PrinaM World Alzheimer Report 2014 Dementia and Risk Reduction AN ANALYSIS OF PROTECTIVE AND MODIFIABLE FACTORS. 2014: Alzheimer's Disease International.

3. Dementia (including Alzheimer's disease) can be prevented: statement supported by international experts;Smith AD;J Alzheimers Dis,2014

4. A Systematic Review of Meta-Analyses that Evaluate Risk Factors for Dementia to Evaluate the Quantity, Quality, and Global Representativeness of Evidence

5. Common risk factors for major noncommunicable disease, a systematic overview of reviews and commentary: the implied potential for targeted risk reduction

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