Lack of genotoxic mechanisms in early-stage furan-induced hepatocellular tumorigenesis ingptdelta rats

Author:

Hibi Daisuke1,Yokoo Yu1,Suzuki Yuta1,Ishii Yuji1,Jin Meilan1,Kijima Aki1,Nohmi Takehiko2,Nishikawa Akiyoshi2,Umemura Takashi1

Affiliation:

1. Division of Pathology; National Institute of Health Sciences; 1-18-1 Kamiyoga Setagaya-ku Tokyo 158-8501 Japan

2. Biological Safety Research Center; National Institute of Health Sciences; 1-18-1 Kamiyoga Setagaya-ku Tokyo 158-8501 Japan

Publisher

Wiley

Subject

Toxicology

Reference32 articles.

1. Toxicity and carcinogenicity of furan in human diet;Bakhiya;Arch. Toxicol.,2010

2. The Wnt/β-catenin signaling pathway in liver biology and disease;Behari;Expert Rev. Gastroenterol. Hepatol.,2010

3. Detection of DNA adducts derived from the reactive metabolite of furan, cis-2-butene-1,4-dial;Byrns;Chem. Res. Toxicol.,2006

4. Phenotypic characterization of metaplastic intestinal glands and ductular hepatocytes in cholangiofibrotic lesions rapidly induced in the caudate liver lobe of rats treated with furan;Elmore;Cancer Res.,1991

5. Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program;Foureman;Environ. Mol. Mutagen.,1994

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