Gene panel testing of 5589 BRCA1/2 -negative index patients with breast cancer in a routine diagnostic setting: results of the German Consortium for Hereditary Breast and Ovarian Cancer-Reference-Cited by-同舟云学术

Gene panel testing of 5589 BRCA1/2 -negative index patients with breast cancer in a routine diagnostic setting: results of the German Consortium for Hereditary Breast and Ovarian Cancer

Published:2018-03-09 Issue:4 Volume:7 Page:1349-1358
ISSN:2045-7634
Container-title:Cancer Medicine
language:en
Short-container-title:Cancer Med

Author:

Hauke Jan¹^ORCID,Horvath Judit²,Groß Eva³,Gehrig Andrea⁴,Honisch Ellen⁵,Hackmann Karl⁶,Schmidt Gunnar⁷,Arnold Norbert⁸,Faust Ulrike⁹,Sutter Christian¹⁰,Hentschel Julia¹¹,Wang-Gohrke Shan¹²,Smogavec Mateja¹³,Weber Bernhard H. F.¹⁴,Weber-Lassalle Nana¹,Weber-Lassalle Konstantin¹,Borde Julika¹,Ernst Corinna¹,Altmüller Janine¹⁵¹⁶¹⁷,Volk Alexander E.¹⁸,Thiele Holger¹⁵¹⁶¹⁷,Hübbel Verena¹,Nürnberg Peter¹⁵¹⁶¹⁷,Keupp Katharina¹,Versmold Beatrix¹,Pohl Esther¹,Kubisch Christian¹⁸,Grill Sabine³,Paul Victoria²,Herold Natalie¹,Lichey Nadine²,Rhiem Kerstin¹,Ditsch Nina¹⁹,Ruckert Christian²,Wappenschmidt Barbara¹,Auber Bernd⁷,Rump Andreas⁶,Niederacher Dieter⁵,Haaf Thomas⁴,Ramser Juliane³,Dworniczak Bernd²,Engel Christoph²⁰²¹,Meindl Alfons³,Schmutzler Rita K.¹,Hahnen Eric¹^ORCID

Affiliation:

1. Center for Hereditary Breast and Ovarian Cancer; Center for Integrated Oncology (CIO); Medical Faculty; University Hospital Cologne; Cologne Germany

2. Institute for Human Genetics; University Hospital Muenster; Muenster Germany

3. Department of Gynaecology and Obstetrics; Division of Tumor Genetics; Klinikum rechts der Isar; Technical University Munich; Munich Germany

4. Institute of Human Genetics; Julius-Maximilians-Universität Würzburg; Würzburg Germany

5. Department of Gynaecology and Obstetrics; University Hospital Duesseldorf; Heinrich-Heine University Duesseldorf; Duesseldorf Germany

6. Institute for Clinical Genetics; Technische Universitaet Dresden; Dresden Germany

7. Department of Human Genetics; Hannover Medical School; Hannover Germany

8. Department of Gynaecology and Obstetrics; Institute of Clinical Molecular Biology; University Hospital of Schleswig-Holstein, Campus Kiel; Christian-Albrechts University Kiel; Kiel Germany

9. Institute of Medical Genetics and Applied Genomics; University Hospital Tuebingen; Tuebingen Germany

10. Institute of Human Genetics; University of Heidelberg; Heidelberg Germany

11. Institute of Human Genetics; University of Leipzig Hospitals and Clinics; Leipzig Germany

12. Department of Gynaecology and Obstetrics; University Hospital Ulm; Ulm Germany

13. Institute of Human Genetics; University Medical Center; Georg August University; Goettingen Germany

14. Institute of Human Genetics; University of Regensburg; Regensburg Germany

15. Cologne Center for Genomics; University of Cologne; Cologne Germany

16. Institute of Human Genetics; University of Cologne; Cologne Germany

17. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD); University of Cologne; Cologne Germany

18. Institute of Human Genetics; University Medical Center Hamburg-Eppendorf; Hamburg Germany

19. Department of Obstetrics and Gynaecology; Ludwig-Maximilians-University of Munich; Munich Germany

20. Institute for Medical Informatics, Statistics and Epidemiology; University of Leipzig; Leipzig Germany

21. LIFE-Leipzig Research Centre for Civilization Diseases; University of Leipzig; Leipzig Germany

Funder

Ministry for Innovation, Science and Research of the State of North Rhine-Westphalia

Deutsche Krebshilfe

European Regional Development Fund

Publisher

Wiley

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology

Reference37 articles.

1. Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers;Kuchenbaecker;JAMA,2017

2. Prevalence of BRCA1/2 germline mutations in 21 401 families with breast and ovarian cancer;Kast;J. Med. Genet.,2016

3. Gene-panel sequencing and the prediction of breast-cancer risk;Easton;N. Engl. J. Med.,2015

4. Associations between cancer predisposition testing panel genes and breast cancer;Couch;JAMA Oncol.,2017

5. A study of over 35,000 women with breast cancer tested with a 25-gene panel of hereditary cancer genes;Buys;Cancer,2017

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