Gene panel testing of 5589 BRCA1/2 -negative index patients with breast cancer in a routine diagnostic setting: results of the German Consortium for Hereditary Breast and Ovarian Cancer-Reference-Cited by-同舟云学术

Gene panel testing of 5589 BRCA1/2 -negative index patients with breast cancer in a routine diagnostic setting: results of the German Consortium for Hereditary Breast and Ovarian Cancer

Published:2018-03-09 Issue:4 Volume:7 Page:1349-1358
ISSN:2045-7634
Container-title:Cancer Medicine
language:en
Short-container-title:Cancer Med

Author:

Hauke Jan¹^ORCID,Horvath Judit²,Groß Eva³,Gehrig Andrea⁴,Honisch Ellen⁵,Hackmann Karl⁶,Schmidt Gunnar⁷,Arnold Norbert⁸,Faust Ulrike⁹,Sutter Christian¹⁰,Hentschel Julia¹¹,Wang-Gohrke Shan¹²,Smogavec Mateja¹³,Weber Bernhard H. F.¹⁴,Weber-Lassalle Nana¹,Weber-Lassalle Konstantin¹,Borde Julika¹,Ernst Corinna¹,Altmüller Janine¹⁵¹⁶¹⁷,Volk Alexander E.¹⁸,Thiele Holger¹⁵¹⁶¹⁷,Hübbel Verena¹,Nürnberg Peter¹⁵¹⁶¹⁷,Keupp Katharina¹,Versmold Beatrix¹,Pohl Esther¹,Kubisch Christian¹⁸,Grill Sabine³,Paul Victoria²,Herold Natalie¹,Lichey Nadine²,Rhiem Kerstin¹,Ditsch Nina¹⁹,Ruckert Christian²,Wappenschmidt Barbara¹,Auber Bernd⁷,Rump Andreas⁶,Niederacher Dieter⁵,Haaf Thomas⁴,Ramser Juliane³,Dworniczak Bernd²,Engel Christoph²⁰²¹,Meindl Alfons³,Schmutzler Rita K.¹,Hahnen Eric¹^ORCID

Affiliation:

1. Center for Hereditary Breast and Ovarian Cancer; Center for Integrated Oncology (CIO); Medical Faculty; University Hospital Cologne; Cologne Germany

2. Institute for Human Genetics; University Hospital Muenster; Muenster Germany

3. Department of Gynaecology and Obstetrics; Division of Tumor Genetics; Klinikum rechts der Isar; Technical University Munich; Munich Germany

4. Institute of Human Genetics; Julius-Maximilians-Universität Würzburg; Würzburg Germany

5. Department of Gynaecology and Obstetrics; University Hospital Duesseldorf; Heinrich-Heine University Duesseldorf; Duesseldorf Germany

6. Institute for Clinical Genetics; Technische Universitaet Dresden; Dresden Germany

7. Department of Human Genetics; Hannover Medical School; Hannover Germany

8. Department of Gynaecology and Obstetrics; Institute of Clinical Molecular Biology; University Hospital of Schleswig-Holstein, Campus Kiel; Christian-Albrechts University Kiel; Kiel Germany

9. Institute of Medical Genetics and Applied Genomics; University Hospital Tuebingen; Tuebingen Germany

10. Institute of Human Genetics; University of Heidelberg; Heidelberg Germany

11. Institute of Human Genetics; University of Leipzig Hospitals and Clinics; Leipzig Germany

12. Department of Gynaecology and Obstetrics; University Hospital Ulm; Ulm Germany

13. Institute of Human Genetics; University Medical Center; Georg August University; Goettingen Germany

14. Institute of Human Genetics; University of Regensburg; Regensburg Germany

15. Cologne Center for Genomics; University of Cologne; Cologne Germany

16. Institute of Human Genetics; University of Cologne; Cologne Germany

17. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD); University of Cologne; Cologne Germany

18. Institute of Human Genetics; University Medical Center Hamburg-Eppendorf; Hamburg Germany

19. Department of Obstetrics and Gynaecology; Ludwig-Maximilians-University of Munich; Munich Germany

20. Institute for Medical Informatics, Statistics and Epidemiology; University of Leipzig; Leipzig Germany

21. LIFE-Leipzig Research Centre for Civilization Diseases; University of Leipzig; Leipzig Germany

Funder

Ministry for Innovation, Science and Research of the State of North Rhine-Westphalia

Deutsche Krebshilfe

European Regional Development Fund

Publisher

Wiley

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology

Reference37 articles.

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2. Prevalence of BRCA1/2 germline mutations in 21 401 families with breast and ovarian cancer;Kast;J. Med. Genet.,2016

3. Gene-panel sequencing and the prediction of breast-cancer risk;Easton;N. Engl. J. Med.,2015

4. Associations between cancer predisposition testing panel genes and breast cancer;Couch;JAMA Oncol.,2017

5. A study of over 35,000 women with breast cancer tested with a 25-gene panel of hereditary cancer genes;Buys;Cancer,2017

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