Culture temperature modulates half antibody and aggregate formation in a Chinese hamster ovary cell line expressing a bispecific antibody
Author:
Affiliation:
1. Pre-Pivotal Drug Substance Technology, Amgen Inc., Thousand Oaks; California
2. Attribute Sciences, Amgen Inc., Thousand Oaks; California
3. Discovery Research, Amgen Inc., Thousand Oaks; California
Publisher
Wiley
Subject
Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/bit.26803/fullpdf
Reference30 articles.
1. Effect of temperature downshift on the transcriptomic responses of chinese hamster ovary cells using recombinant human tissue plasminogen activator production culture;Bedoya-López;PLOS One,2016
2. Design of therapeutic proteins with enhanced stability;Chennamsetty;Proceedings of the National Academy of Sciences of the United States of America,2009
3. Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells;Dillon;MAbs,2017
4. CHO cell engineering to prevent polypeptide aggregation and improve therapeutic protein secretion;Le Fourn;Metabolic Engineering,2014
5. Bispecific antibody process development: Assembly and purification of knob and hole bispecific antibodies;Giese;Biotechnology Progress,2017
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