A small disturbance, but a serious disease: The possible mechanism of D52H-mutant of human PRS1 that causes gout

Author:

Chen Peng,Li Jianzhong,Ma Jin,Teng Maikun,Li Xu

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Genetics,Molecular Biology,Biochemistry

Reference30 articles.

1. Human phosphoribosylpyrophosphate synthetase. Kinetic mechanism and end product inhibition;Fox;J. Biol. Chem.,1972

2. Overexpression of the normal phosphoribosylpyrophosphate synthetase 1 isoform underlies catalytic superactivity of human phosphoribosylpyrophosphate synthetase;Becker;J. Biol. Chem.,1996

3. Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site;Li;Biochem. J.,2007

4. PRPS1 mutations: four distinct syndromes and potential treatment;de Brouwer;Am. J. Hum. Genet.,2010

5. Inhibition of phosphoribosylpyrophosphate synthesis in human fibroblasts by 6-methylthioinosinate;Yen;J. Biol. Chem.,1981

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