Cancer phase I trial design using drug combinations when a fraction of dose limiting toxicities is attributable to one or more agents

Author:

Jimenez Jose L.1ORCID,Tighiouart Mourad2,Gasparini Mauro1ORCID

Affiliation:

1. Politecnico di Torino; Dipartimento di Scienze Matematiche; Corso Duca degli Abruzzi, 24 10129 Turin Italy

2. Samuel Oschin Comprehensive Cancer Institute; Los Angeles CA 90048 USA

Funder

National Institutes of Health

National Center for Research Resources

H2020 Marie Skłodowska-Curie Actions

National Center for Advancing Translational Sciences

Publisher

Wiley

Subject

Statistics, Probability and Uncertainty,General Medicine,Statistics and Probability

Reference25 articles.

1. Cancer phase i clinical trials: efficient dose escalation with overdose control;Babb;Statistics in Medicine,1998

2. A hierarchical Bayesian design for phase I trials of novel combinations of cancer therapeutic agents;Braun;Biometrics,2010

3. A curve-free method for phase I clinical trials;Gasparini;Biometrics,2000

4. Phase I designs that allow for uncertainty in the attribution of adverse events;Iasonos;Journal of the Royal Statistical Society: Series C (Applied Statistics),2016

5. A two-dimensional search algorithm for dose-finding trials of two agents;Lee;Journal of Biopharmaceutical Statistics,2012

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