Inorganic nanoparticle‐integrated mesenchymal stem cells: A potential biological agent for multifaceted applications

Author:

Zheng Juan‐Juan1,Jiang Xin‐Chi1,Li Yao‐Sheng1,Gao Jian‐Qing123

Affiliation:

1. Institute of Pharmaceutics College of Pharmaceutical Sciences Zhejiang University Hangzhou China

2. Hangzhou Institute of Innovative Medicine College of Pharmaceutical Sciences Zhejiang University Hangzhou China

3. Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang University Hangzhou China

Abstract

AbstractMesenchymal stem cell (MSC)‐based therapies are flourishing. MSCs could be used as potential therapeutic agents for regenerative medicine due to their own repair function. Meanwhile, the natural predisposition toward inflammation or injury sites makes them promising carriers for targeted drug delivery. Inorganic nanoparticles (INPs) are greatly favored for their unique properties and potential applications in biomedical fields. Current research has integrated INPs with MSCs to enhance their regenerative or antitumor functions. This model also allows the in vivo fate tracking of MSCs in multiple imaging modalities, as many INPs are also excellent contrast agents. Thus, INP‐integrated MSCs would be a multifunctional biologic agent with great potential. In this review, the current roles performed by the integration of INPs with MSCs, including (i) enhancing their repair and regeneration capacity via the improvement of migration, survival, paracrine, or differentiation properties, (ii) empowering tumor‐killing ability through agent loaded or hyperthermia, and (iii) conferring traceability are summarized. An introduction of INP‐integrated MSCs for simultaneous treatment and tracking is also included. The promising applications of INP‐integrated MSCs in future treatments are emphasized and the challenges to their clinical translation are discussed.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

Wiley

Subject

Cell Biology,Biochemistry (medical),Genetics (clinical),Computer Science Applications,Drug Discovery,Genetics,Oncology,Immunology and Allergy

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