Apilimod enhances specific productivity in recombinant CHO cells through cell cycle arrest and mediation of autophagy-Reference-Cited by-同舟云学术

Apilimod enhances specific productivity in recombinant CHO cells through cell cycle arrest and mediation of autophagy

Published:2022-12-14 Issue:2 Volume:18 Page:2200147
ISSN:1860-6768
Container-title:Biotechnology Journal
language:en
Short-container-title:Biotechnology Journal

Author:

Lu Jiang‐Tao¹²³,Xiao Meng‐Ke²³⁴,Feng Ying‐Ying¹²³,Wang Xiao‐Yin²³⁵^ORCID,Qiu Le‐Le⁵,Chai Yu‐Rong⁶,Wang Tian‐Yun²³⁵^ORCID,Jia Yan‐Long¹²³^ORCID

Affiliation:

1. School of Pharmacy Xinxiang Medical University Xinxiang Henan China

2. International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan Xinxiang Medical University Xinxiang Henan China

3. Henan Engineering Research Center for Biopharmaceutical Innovation Xinxiang Medical University Xinxiang Henan China

4. School of Public Health Xinxiang Medical University Xinxiang Henan China

5. School of Basic Medicine Xinxiang Medical University Xinxiang Henan China

6. Department of Histology and Embryology School of Basic Medical Sciences Zhengzhou University Zhengzhou Henan China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/biot.202200147

Reference48 articles.

1. Biopharmaceutical benchmarks 2018

2. Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions

3. The role of protein hydrolysates in prolonging viability and enhancing antibody production of CHO cells

4. Knockout of sialidase and pro-apoptotic genes in Chinese hamster ovary cells enables the production of recombinant human erythropoietin in fed-batch cultures

5. CRISPR /Cas9‐mediated gene knockout for DNA methyltransferase Dnmt3a in CHO cells displays enhanced transgenic expression and long‐term stability

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