Continuous optical in‐line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality-Reference-Cited by-同舟云学术

Continuous optical in‐line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality

Published:2021-06-04 Issue:8 Volume:16 Page:2100088
ISSN:1860-6768
Container-title:Biotechnology Journal
language:en
Short-container-title:Biotechnol. J.

Author:

Lederle Mario¹²,Tric Mircea¹²,Roth Tatjana¹,Schütte Lina³,Rattenholl Anke⁴,Lütkemeyer Dirk⁴,Wölfl Stefan²,Werner Tobias¹,Wiedemann Philipp⁵

Affiliation:

1. Department of Biotechnology Institute of Analytical Chemistry Mannheim University of Applied Sciences Mannheim Germany

2. Pharmaceutical Biology, Bioanalytics and Molecular Biology Institute of Pharmacy and Molecular Biotechnology Heidelberg University Heidelberg Germany

3. Center for Applied Chemistry Institute of Food Chemistry Gottfried Wilhelm Leibniz University Hannover Germany

4. Faculty of Engineering and Mathematics Institute of Biotechnological Process Engineering Bielefeld University of Applied Sciences Bielefeld Germany

5. Department of Biotechnology Institute of Molecular and Cell Biology Mannheim University of Applied Sciences Mannheim Germany

Funder

Bundesministerium für Bildung und Forschung

Publisher

Wiley

Subject

Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/biot.202100088

Reference38 articles.

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2. Biopharmaceutical benchmarks 2018

3. A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing

4. In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors

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