Author:
Rolinger Laura,Rüdt Matthias,Hubbuch Jürgen
Abstract
AbstractAs competition in the biopharmaceutical market gets keener due to the market entry of biosimilars, process analytical technologies (PATs) play an important role for process automation and cost reduction. This article will give a general overview and address the recent innovations and applications of spectroscopic methods as PAT tools in the downstream processing of biologics. As data analysis strategies are a crucial part of PAT, the review discusses frequently used data analysis techniques and addresses data fusion methodologies as the combination of several sensors is moving forward in the field. The last chapter will give an outlook on the application of spectroscopic methods in combination with chemometrics and model predictive control (MPC) for downstream processes.
Publisher
Springer Science and Business Media LLC
Subject
Biochemistry,Analytical Chemistry
Cited by
79 articles.
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