New soluble angiopoietin analog of Hepta‐ANG1 prevents pathological vascular leakage

Author:

Liu Pan1ORCID,Ryczko Michael2,Xie Xinfang13,Baardsnes Jason4,Lord‐Dufour Simon4,Duroche Yves4,Hicks Emily Anne5,Taiyab Aftab5,Sheardown Heather5,Quaggin Susan E.1,Jin Jing1

Affiliation:

1. Department of Medicine/Nephrology, Feinberg School of Medicine, Feinberg Cardiovascular and Renal Research Institute Northwestern University Chicago Illinois USA

2. Mannin Research, Inc. Toronto Ontario Canada

3. Department of Nephrology, The First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an China

4. Human Health Therapeutics Research Centre National Research Council of Canada Montreal Qubec Canada

5. Department of Chemical Engineering McMaster University Hamilton Ontario Canada

Funder

National Institutes of Health

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference41 articles.

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2. Visualizing proteins and macromolecular complexes by negative stain EM: From grid preparation to image acquisition;Booth D. S.;JoVE,2011

3. Evaluating vascular hyperpermeability‐inducing agents in the skin with the Miles assay;Brash J. T.;JoVE,2018

4. COMP‐Ang1: A designed angiopoietin‐1 variant with nonleaky angiogenic activity;Cho C.‐H.;Proceedings of the National Academy of Sciences of the United States of America,2004

5. Designed angiopoietin‐1 variant, COMP‐Ang1, protects against radiation‐induced endothelial cell apoptosis;Cho C.‐H.;Proceedings of the National Academy of Sciences of the United States of America,2004

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