Drug metabolite identification using ultrahigh‐performance liquid chromatography–ultraviolet spectroscopy and parallelized scans on a tribrid Orbitrap mass spectrometer-Reference-Cited by-同舟云学术

Drug metabolite identification using ultrahigh‐performance liquid chromatography–ultraviolet spectroscopy and parallelized scans on a tribrid Orbitrap mass spectrometer

Published:2020-03-09 Issue:10 Volume:34 Page:
ISSN:0951-4198
Container-title:Rapid Communications in Mass Spectrometry
language:en
Short-container-title:Rapid Commun Mass Spectrom

Author:

Wilkinson Stephen D.¹^ORCID,Martin Scott¹,Orton Alexandra L.¹,Markandu Roshini¹,Jones Barry C.¹

Affiliation:

1. DMPK/ADME Research and Early Development, Oncology R&DAstraZeneca Cambridge UK

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/rcm.8735

Reference31 articles.

1. Metabolic Soft Spot Identification and Compound Optimization in Early Discovery Phases Using MetaSite and LC-MS/MS Validation

2. Liquid chromatography/atmospheric pressure ionization‐mass spectrometry in drug metabolism studies;Kostianen R;J Mass Spectrom,2003

3. Pharmacologically Active Drug Metabolites: Impact on Drug Discovery and Pharmacotherapy

4. Studies on cytochrome P‐450‐mediated bioactivation of diclofenac in rats and in human hepatocytes: Identification of glutathione conjugated metabolites;Tang W;Drug Metab Dispos,1999

5. Rapid screening and characterization of glutathione-trapped reactive metabolites using a polarity switch-based approach on a high-resolution quadrupole orbitrap mass spectrometer

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Global Xenobiotic Profiling of Rat Plasma Using Untargeted Metabolomics and Background Subtraction-Based Approaches: Method Evaluation and Comparison;Current Drug Metabolism;2023-03

2. Quantitative Relations Among Measurands of Molecular Isotopologies of Halogenated Pharmaceutics – Stochastic Dynamic Mass Spectrometric Approach;SSRN Electronic Journal;2023

3. A high‐resolution accurate mass approach to identification of graveoline metabolites using ultra‐high‐performance liquid chromatography combined with a photo diode array detector and quadrupole/time‐of‐flight tandem mass spectrometry;Biomedical Chromatography;2022-10-07

4. Rapid separation and identification of 96 main constituents in Huanglian Jiedu decoction via ultra‐high performance liquid chromatography–Orbitrap Fusion Tribrid mass spectrometer;Journal of Mass Spectrometry;2022-10

5. Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations;Xenobiotica;2022-08-03