Drug metabolite identification using ultrahigh‐performance liquid chromatography–ultraviolet spectroscopy and parallelized scans on a tribrid Orbitrap mass spectrometer-Reference-Cited by-同舟云学术

Drug metabolite identification using ultrahigh‐performance liquid chromatography–ultraviolet spectroscopy and parallelized scans on a tribrid Orbitrap mass spectrometer

Published:2020-03-09 Issue:10 Volume:34 Page:
ISSN:0951-4198
Container-title:Rapid Communications in Mass Spectrometry
language:en
Short-container-title:Rapid Commun Mass Spectrom

Author:

Wilkinson Stephen D.¹^ORCID,Martin Scott¹,Orton Alexandra L.¹,Markandu Roshini¹,Jones Barry C.¹

Affiliation:

1. DMPK/ADME Research and Early Development, Oncology R&DAstraZeneca Cambridge UK

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/rcm.8735

Reference31 articles.

1. Metabolic Soft Spot Identification and Compound Optimization in Early Discovery Phases Using MetaSite and LC-MS/MS Validation

2. Liquid chromatography/atmospheric pressure ionization‐mass spectrometry in drug metabolism studies;Kostianen R;J Mass Spectrom,2003

3. Pharmacologically Active Drug Metabolites: Impact on Drug Discovery and Pharmacotherapy

4. Studies on cytochrome P‐450‐mediated bioactivation of diclofenac in rats and in human hepatocytes: Identification of glutathione conjugated metabolites;Tang W;Drug Metab Dispos,1999

5. Rapid screening and characterization of glutathione-trapped reactive metabolites using a polarity switch-based approach on a high-resolution quadrupole orbitrap mass spectrometer

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