Efficient Strategy for Detecting Gene × Gene Joint Action and Its Application in Schizophrenia

Author:

Won Sungho12,Kwon Min-Seok3,Mattheisen Manuel45,Park Suyeon1,Park Changsoon12,Kihara Daisuke6,Cichon Sven457,Ophoff Roel8,Nöthen Markus M.45,Rietschel Marcella9,Baur Max1011,Uitterlinden Andre G.1213,Hofmann A.13,Lange Christoph11141516,

Affiliation:

1. Department of Applied Statistics; Chung-Ang University; Seoul Korea

2. Research Center for Data Science; Chung-Ang University; Seoul Korea

3. Bioinformatics Program; Seoul National University; Seoul Korea

4. Institute of Human Genetics; University of Bonn; Bonn Germany

5. Department of Genomics; Life and Brain Center; University of Bonn; Bonn Germany

6. Department of Computer Sciences; Purdue University; West Lafayette Indiana United States of America

7. Institute of Neuroscience and Medicine (INM-1); Research Center Juelich; Juelich Germany

8. Department of Medical Genetics, Rudolf Magnus Institute of Neuroscience; University Medical Center Utrecht; Utrecht The Netherlands

9. Department of Genetic Epidemiology in Psychiatry; Central Institute of Mental Health, University of Mannheim; Mannheim Germany

10. Institute for Medical Biometry; Informatics, and Epidemiology, University of Bonn; Bonn Germany

11. German Center for Neurodegenerative Diseases (DZNE); Bonn Germany

12. Department of Internal Medicine; Genetics Laboratory; Eramsmus Medical Center Rotterdam; The Netherlands

13. Department of Epidemiology, Erasmus University Medical Center; Rotterdam The Netherlands

14. Institute for Genomic Mathematics; University of Bonn; Bonn Germany

15. Department of Biostatistics; Harvard School of Public Health; Boston Massachusetts United States of America

16. Center for Genomic Medicine; Brigham and Women's Hospital; Boston Massachusetts United States of America

Funder

Korean Government

Publisher

Wiley

Subject

Genetics (clinical),Epidemiology

Reference62 articles.

1. Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort;Athanasiu;J Psychiatr Res,2010

2. Serum malondialdehyde and mitochondrial aspartate aminotransferase activity as markers of chronic alcohol intake and alcoholic liver disease;Baldi;Ital J Gastroenterol,1993

3. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease;Barrett;Nat Genet,2008

4. Combining independent tests of significance;Birnbaum;J Am Stat Assoc,1954

5. Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics;Cardno;Am J Med Genet,2000

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