Microfluidics approach to investigate the role of dynamic similitude in osteocyte mechanobiology

Author:

Middleton Kevin1ORCID,Kondiboyina Avinash2,Borrett Michael3,Cui Yi4,Mei Xueting4,You Lidan14

Affiliation:

1. Institute of Biomaterials and Biomedical Engineering; University of Toronto; 164 College Street, Room 407 Toronto Ontario M5S 3G9 Canada

2. Division of Engineering Science; University of Toronto; 40 Saint George Street, Room 2110 Toronto Ontario M5S 2E4 Canada

3. Department of Biochemistry; McMaster University; 1280 Main Street West, Room 4N59 Hamilton Ontario L8S 4L8 Canada

4. Department of Mechanical and Industrial Engineering; University of Toronto; 5 King's College Road, Room 105 Toronto Ontario M5S 3G8 Canada

Funder

Natural Sciences and Engineering Research Council of Canada

Toronto Musculoskeletal Centre

Barbara and Frank Milligan

Canadian Institutes of Health Research

Canada Foundation for Innovation

Publisher

Wiley

Subject

Orthopedics and Sports Medicine

Reference46 articles.

1. Fluid shear stress and the vascular endothelium: for better and for worse;Resnick;Prog Biophys Mol Biol,2003

2. From streaming potentials to shear stress: 25 Years of bone cell mechanotransduction;Riddle;J Orthop Res,2009

3. Effect of oscillating fluid flow stimulation on osteocyte mRNA expression;Li;J Biomech,2012

4. Exposure to fluid shear stress modulates the ability of endothelial cells to recruit neutrophils in response to tumor necrosis factor-α: a basis for local variations in vascular sensitivity to inflammation;Sheikh;Blood,2003

5. Structure-function relationships in the stem cell's mechanical world B: emergent anisotropy of the cytoskeleton correlates to volume and shape changing stress exposure;Chang;Mol Cell Biomech,2011

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