Effects of fumarates on circulating and CNS myeloid cells in multiple sclerosis-Reference-Cited by-同舟云学术

Effects of fumarates on circulating and CNS myeloid cells in multiple sclerosis

Published:2015-12-02 Issue:1 Volume:3 Page:27-41
ISSN:2328-9503
Container-title:Annals of Clinical and Translational Neurology
language:en
Short-container-title:Ann Clin Transl Neurol

Author:

Michell‐Robinson Mackenzie A.¹,Moore Craig S.²,Healy Luke M.¹,Osso Lindsay A.¹,Zorko Nika¹,Grouza Vladimir³,Touil Hanane¹,Poliquin‐Lasnier Laurence¹,Trudelle Anne‐Marie¹,Giacomini Paul S.¹,Bar‐Or Amit¹,Antel Jack P.¹

Affiliation:

1. Neuroimmunology Unit Department of Neurology and Neurosurgery Montreal Neurological Institute and Hospital McGill University Montreal Quebec Canada

2. Division of BioMedical Sciences Faculty of Medicine Memorial University St. John's Newfoundland Canada

3. Institute of Biomaterials and Biomedical Engineering University of Toronto Toronto Ontario Canada

Funder

Canadian Institutes of Health Research

Multiple Sclerosis Society of Canada

Biogen Idec

Publisher

Wiley

Subject

Clinical Neurology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/acn3.270

Reference34 articles.

1. Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy.

2. Increased percentage of IL-12+ monocytes in the blood correlates with the presence of active MRI lesions in MS

3. Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells

4. DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner

5. Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

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