Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells

Author:

Foresti Roberta,Bains Sandip K.,Pitchumony Tamil Selvi,de Castro Brás Lisandra E.,Drago Filippo,Dubois-Randé Jean-Luc,Bucolo Claudio,Motterlini Roberto

Funder

AREMCAR Foundation

International PhD Program in Neuropharmacology, Medical School, University of Catania

Publisher

Elsevier BV

Subject

Pharmacology

Reference45 articles.

1. Microglia and mast cells: two tracks on the road to neuroinflammation;Skaper;FASEB J,2012

2. Targeting heme oxygenase-1 for neuroprotection and neuroinflammation in neurodegenerative diseases;Jazwa;Curr Drug Targets,2010

3. The transcription factor Nrf2 is a therapeutic target against brain inflammation;Innamorato;J Immunol,2008

4. Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice;Yoh;Genes Cells,2008

5. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis;Thimmulappa;J Clin Invest,2006

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