Subchondral Bone Trabecular Integrity Predicts and Changes Concurrently With Radiographic and Magnetic Resonance Imaging-Determined Knee Osteoarthritis Progression

Author:

Kraus Virginia Byers1,Feng Sheng1,Wang ShengChu1,White Scott1,Ainslie Maureen1,Graverand Marie-Pierre Hellio Le2,Brett Alan3,Eckstein Felix4,Hunter David J.5,Lane Nancy E.6,Taljanovic Mihra S.7,Schnitzer Thomas8,Charles H. Cecil1

Affiliation:

1. Duke University; Durham; North Carolina

2. Pfizer Global Research and Development; Groton; Connecticut

3. Optasia Medical; Manchester; UK

4. Paracelsus Medical University, Salzburg, Austria, and Chondrometrics GmbH; Ainring; Germany

5. New England Baptist Hospital, Boston, Massachusetts, and University of Sydney; Sydney; Australia

6. University of California at Davis Medical Center; Sacramento

7. University of Arizona; Tucson

8. Northwestern University; Chicago; Illinois

Publisher

Wiley

Subject

Pharmacology (medical),Immunology,Rheumatology,Immunology and Allergy

Reference53 articles.

1. Is osteoarthritis a disease involving only cartilage or other articular tissues?;Martel-Pelletier;Eklem Hastalik Cerrahisi,2010

2. Targeting subchondral bone for treating osteoarthritis: what is the evidence?;Kwan Tat;Best Pract Res Clin Rheumatol,2010

3. Osteoporotic changes of subchondral trabecular bone in osteoarthritis of the knee: a 3-T MRI study;Chiba;Osteoporos Int,2012

4. The bone-cartilage unit in osteoarthritis;Lories;Nat Rev Rheumatol,2011

5. Osteoarthritic cartilage chondrocytes alter subchondral bone osteoblast differentiation via MAPK signalling pathway involving ERK1/2;Prasadam;Bone,2010

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