A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes
Author:
Affiliation:
1. Lilly Research Laboratories Indianapolis Indiana
2. Jubilant BioSys Ltd. Bangalore India
Funder
Eli Lilly and Company
Publisher
Wiley
Subject
General Pharmacology, Toxicology and Pharmaceutics,Neurology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.278
Reference23 articles.
1. Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets
2. GPR40-induced insulin secretion by the novel agonist TAK-875: first clinical findings in patients with type 2 diabetes
3. The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids
4. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules
5. A Family of Fatty Acid Binding Receptors
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