Affiliation:
1. CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for NanoScience and Technology Beijing 100190 P. R. China
2. University of Chinese Academy of Sciences Beijing 100049 P. R. China
3. School of Materials Science and Engineering Zhengzhou University Zhengzhou 450001 P. R. China
Abstract
AbstractDNA molecules that store genetic information in living creatures can be repurposed as building blocks to construct artificial architectures, ranging from the nanoscale to the microscale. The precise fabrication of self‐assembled DNA nanomaterials and their various applications have greatly impacted nanoscience and nanotechnology. More specifically, the DNA origami technique has realized the assembly of various nanostructures featuring rationally predesigned geometries, precise addressability, and versatile programmability, as well as remarkable biocompatibility. These features have elevated DNA origami from academic interest to an emerging class of drug delivery platform for a wide range of diseases. In this minireview, the latest advances in the burgeoning field of DNA‐origami‐based innovative platforms for regulating biological functions and delivering versatile drugs are presented. Challenges regarding the novel drug vehicle's safety, stability, targeting strategy, and future clinical translation are also discussed.
Funder
National Natural Science Foundation of China
Youth Innovation Promotion Association
K. C. Wong Education Foundation
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
9 articles.
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