Three-Dimensional Structures Self-Assembled from DNA Bricks-Reference-Cited by-同舟云学术

Three-Dimensional Structures Self-Assembled from DNA Bricks

Published:2012-11-30 Issue:6111 Volume:338 Page:1177-1183
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ke Yonggang¹²³,Ong Luvena L.¹⁴,Shih William M.¹²³,Yin Peng¹⁵

Affiliation:

1. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

2. Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.

3. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Harvard University, Boston, MA 02115, USA.

4. Harvard–Massachusetts Institute of Technology (MIT) Division of Health Sciences and Technology, MIT, Cambridge, MA 02139, USA.

5. Department of Systems Biology, Harvard Medical School, Harvard University, Boston, MA 02115, USA.

Abstract

Building with DNA One route for assembling three-dimensional (3D) DNA nanostructures is to start with a long natural DNA single strand and attach short strands, or “staples,” that cause the entire “origami” structure to fold into a desired shape. Ke et al. (p. 1177 , see the cover; see the Perspective by

Gothelf

) present an alternative approach to 3D assembly that builds upon modular assembly of 2D DNA tiles. One hundred and two distinct shapes were created from four-domain, 32-nucleotide single-stranded DNAs that assembled like children's blocks; each block could bind to four neighboring blocks through specific pairing interactions. Computer design and stepwise assembly allowed assembly of hollow shapes with a variety of internal cavities.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. Nucleic acid junctions and lattices

2. Synthesis from DNA of a molecule with the connectivity of a cube

3. DNA double-crossover molecules

4. Design and self-assembly of two-dimensional DNA crystals

5. A DNA-fuelled molecular machine made of DNA

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