Affiliation:
1. College of Chemistry and Molecular Sciences Key Laboratory of Biomedical Polymers‐Ministry of Education Department of Hematology of Zhongnan Hospital Taikang Center for Life and Medical Sciences Wuhan University Wuhan 430072 China
2. Department of Thyroid and Breast Surgery Zhongnan Hospital of Wuhan University School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China
3. Department of Thyroid and Breast Surgery Zhongnan Hospital of Wuhan University Wuhan 430071 China
Abstract
AbstractNucleic acid plays a crucial role in countless biological processes. Hence, there is great interest in its detection and analysis in various fields from chemistry, biology, to medicine. Nanoporous crystalline materials exhibit enormous potential as an effective platform for nucleic acid recognition and application. These materials have highly ordered and uniform pore structures, as well as adjustable surface chemistry and pore size, making them good carriers for nucleic acid extraction, detection, and delivery. In this review, the latest developments in nanoporous crystalline materials, including metal organic frameworks (MOFs), covalent organic frameworks (COFs), and supramolecular organic frameworks (SOFs) for nucleic acid recognition and applications are discussed. Different strategies for functionalizing these materials are explored to specifically identify nucleic acid targets. Their applications in selective separation and detection of nucleic acids are highlighted. They can also be used as DNA/RNA sensors, gene delivery agents, host DNAzymes, and in DNA‐based computing. Other applications include catalysis, data storage, and biomimetics. The development of novel nanoporous crystalline materials with enhanced biocompatibility has opened up new avenues in the fields of nucleic acid analysis and therapy, paving the way for the development of sensitive, selective, and cost‐effective diagnostic and therapeutic tools with widespread applications.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
2 articles.
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