Affiliation:
1. Department of Ultrasound Zhongshan Hospital Fudan University and Shanghai Institute of Medical Imaging Shanghai 200032 P. R. China
2. Institute of Medical Ultrasound and Engineering Fudan University Shanghai 200032 P. R. China
3. Materdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. China
Abstract
AbstractUltrasound (US)‐triggered cascade amplification of nanotherapies has attracted considerable attention as an effective strategy for cancer treatment. With the remarkable advances in materials chemistry and nanotechnology, a large number of well‐designed nanosystems have emerged that incorporate presupposed cascade amplification processes and can be activated to trigger therapies such as chemotherapy, immunotherapy, and ferroptosis, under exogenous US stimulation or specific substances generated by US actuation, to maximize antitumor efficacy and minimize detrimental effects. Therefore, summarizing the corresponding nanotherapies and applications based on US‐triggered cascade amplification is essential. This review comprehensively summarizes and highlights the recent advances in the design of intelligent modalities, consisting of unique components, distinctive properties, and specific cascade processes. These ingenious strategies confer unparalleled potential to nanotherapies based on ultrasound‐triggered cascade amplification and provide superior controllability, thus overcoming the unmet requirements of precision medicine and personalized treatment. Finally, the challenges and prospects of this emerging strategy are discussed and it is expected to encourage more innovative ideas and promote their further development.
Funder
National Natural Science Foundation of China
Shanghai Shuguang Program
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献