Affiliation:
1. School of Food and Biological Engineering Jiangsu University; International Joint Research Laboratory of Intelligent Agriculture and Agri‐products Processing (Jiangsu University) Jiangsu Education Department Zhenjiang 212013 P. R. China
2. Analysis and Testing Center Jiangsu University Zhenjiang 212013 P. R. China
3. School of Light Industry Beijing Technology and Business University Beijing 100048 P. R. China
4. Department of Environmental Science and Engineering University of Shanghai for Science and Technology Shanghai 200093 P. R. China
Abstract
AbstractThe development of environment‐friendly bacteriostats in humid atmosphere is designated as a crucial step pointing to sustainable antibiotic‐free alterative. Thanks to the excellent biosafety and intrinsic bacteriostatic attributes, bioactive phytochemical formulations become a fascinating substitute for traditional antibiotics; yet, it remains a challenge to deliver them toward moisture‐activated bacteriostatic application due to the unclear release mechanism and bacteriostatic behavior. Benefitting from “green” metal–organic frameworks (MOFs) evolved from natural γ‐cyclodextrin (γ‐CD) and potassium ion (K+), an intelligent moisture‐activated phytochemical formulation is developed, which is featured by grafting bacteriostatic vanillin (a specific phytochemical extracted from Rutaceae vanilla bean) into microporous structure of MOFs via ligand implantation mechanism. According to the molecular simulation docking, the dominant pattern of host–guest structure is characteristic for H‐bond with a length of 1.9 Å, beneficial for the sterling adsorption capacity. Nevertheless, under moisture exposure, the intermolecular H‐bond is disrupted for vanillin release to destroy bacterial membrane structure, accelerate protein decomposition, and especially inhibit virulence gene transcription of cfa gene in Escherichia coli and sea gene in Staphylococcus aureus, directing to upgrade the insights into the bacteriostatic potency of phytochemicals in high‐humidity circumstance.
Funder
National Key Research and Development Program of China
Natural Science Foundation of Jiangsu Province
National Natural Science Foundation of China
Subject
Electrochemistry,Condensed Matter Physics,Biomaterials,Electronic, Optical and Magnetic Materials