Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction-Reference-Cited by-同舟云学术

Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction

Published:2016-06-15 Issue:5 Volume:36 Page:789-844
ISSN:0198-6325
Container-title:Medicinal Research Reviews
language:en
Short-container-title:Med. Res. Rev.

Author:

Lemos Agostinho¹,Leão Mariana²,Soares Joana²,Palmeira Andreia¹,Pinto Madalena¹³,Saraiva Lucília²,Sousa Maria Emília¹³

Affiliation:

1. Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy; University of Porto; Rua de Jorge Viterbo Ferreira, 228 4050-313 Porto Portugal

2. UCIBIO/REQUIMTE, Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy; University of Porto; Rua de Jorge Viterbo Ferreira, 228 4050-313 Porto Portugal

3. CIIMAR-Interdisciplinary Centre of Marine and Environmental Research; University of Porto; Rua de Bragas, 289 4050-123 Porto Portugal

Publisher

Wiley

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Reference199 articles.

1. Inhibition of tumor angiogenesis by p53: A new role for the guardian of the genome;Teodoro;J Mol Med (Berl),2007

2. Control of apoptosis by p53;Fridman;Oncogene,2003

3. Regulation of p53 downstream genes;el-Deiry;Semin Cancer Biol,1998

4. Cancer. p53, guardian of the genome;Nature,1992

5. The p53 orchestra: MDM2 and MDMX set the tone;Wade;Trends Cell Biol,2010

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