High‐throughput protein precipitation method with 96‐well plate for determination of doxepin and nordoxepin in human plasma using LC

High‐throughput protein precipitation method with 96‐well plate for determination of doxepin and nordoxepin in human plasma using LC–MS/MS

Published:2020-04-23 Issue:8 Volume:34 Page:
ISSN:0269-3879
Container-title:Biomedical Chromatography
language:en
Short-container-title:Biomedical Chromatography

Author:

Margaryan Tigran¹^ORCID,Sargsyan Mariam¹,Gevorgyan Arpine¹,Zakaryan Hasmik¹,Aleksanyan Armine¹,Harutyunyan Armen¹,Armoudjian Yeghig¹,Mikayelyan Astghik¹^ORCID

Affiliation:

1. DarmanTest Laboratories LLC Yerevan Armenia

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bmc.4844

Reference11 articles.

1. Determination of doxepin and desmethyldoxepin in human plasma using liquid chromatography–tandem mass spectrometry

2. Effects of doxepin on brain‐derived neurotrophic factor, tumor necrosis factor alpha, mitogen‐activated protein kinase 14, and AKT1 genes expression in rat hippocampus;Eidelkhani N.;Advanced Biomedical Research,2015

3. European Medicines Agency. (2011).Guideline on bioanalytical method validation. Retrieved fromhttps://www.ema.europa.eu/en/documents/scientific-guideline/guideline-bioanalytical-method-validation_en.pdf

4. Quantification of Tricyclic Antidepressants Using UPLC-MS/MS

5. A Fatal Doxepin Poisoning Associated With a Defective CYP2D6 Genotype

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