Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain-Reference-Cited by-同舟云学术

Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain

Published:2016-06-01 Issue:2 Volume:54 Page:1228-1235
ISSN:0022-152X
Container-title:Journal of Heterocyclic Chemistry
language:en
Short-container-title:J. Heterocyclic Chem.

Author:

Vardanyan Ruben S.¹,Cain James P.¹,Haghighi Saghar Mowlazadeh¹,Kumirov Vlad K.¹,McIntosh Mary I.²,Sandweiss Alexander J.²^ORCID,Porreca Frank²,Hruby Victor J.¹

Affiliation:

1. Department of Chemistry and Biochemistry; University of Arizona; Tucson Arizona 85721 USA

2. Department of Pharmacology; University of Arizona Health Sciences Center; Tucson Arizona 85724 USA

Funder

U.S. Public Health Service National Institute of Health

Publisher

Wiley

Subject

Organic Chemistry

Reference54 articles.

1. Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain

2. Opioid ligands with mixed μ/δ opioid receptor interactions: An emerging approach to novel analgesics

3. New paradigms and tools in drug design for pain and addiction

4. Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile

5. Evolution of the Bifunctional Lead μ Agonist/δ Antagonist Containing the 2′,6′-Dimethyl-l-tyrosine−1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Dmt−Tic) Opioid Pharmacophore

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