New oxadiazol‐5‐ones derivatives and their performance as angiotensin‐converting enzyme (ACE) inhibitors

Author:

Ferreira Larissa Fernanda Lima1ORCID,Lins Ilária Martina Silva1ORCID,Feitosa Sidney Gustavo Diniz1ORCID,Ferreira Jivaldo Gonçalves2ORCID,Maciel Larissa Gonçalves1ORCID,Araújo Alice Valença2ORCID,dos Anjos Janaína Versiani1ORCID

Affiliation:

1. Department of Fundamental Chemistry Federal University of Pernambuco Recife Brazil

2. Vitória Academic Centre (CAV) Federal University of Pernambuco Vitória de Santo Antão Brazil

Abstract

AbstractAngiotensin‐converting enzyme inhibitors are widely used in treating arterial hypertension, acting on the renin‐angiotensin‐aldosterone system and controlling blood pressure. We present a novel, greener, and faster methodology to assess the 1,2,4‐oxadiazol‐5‐one ring and perform molecular modifications to obtain angiotensin‐converting enzyme (ACE) inhibitors using this heterocyclic core. Molecular docking simulations indicate that the tested compounds exhibited an affinity for the ACE binding site, with scores comparable to the commercial inhibitor lisinopril. However, in vitro assays revealed that the compounds were ineffective in inhibiting ACE activity. The lack of inhibition may be related to the compounds' more apolar nature. These results emphasize the importance of integrating computational and experimental approaches in developing new drugs, providing valuable insights for planning future studies to optimize the activity of synthesized compounds.

Funder

Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Wiley

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