Chemical synthesis, absolute configuration, and stereochemistry of formation of 10-hydroxywarfarin: A major oxidative metabolite of (+)-(r)-warfarin from hepatic microsomal preparations-Reference-Cited by-同舟云学术

Chemical synthesis, absolute configuration, and stereochemistry of formation of 10-hydroxywarfarin: A major oxidative metabolite of (+)-(r)-warfarin from hepatic microsomal preparations

Published:1990 Issue:2 Volume:2 Page:96-105
ISSN:0899-0042
Container-title:Chirality
language:en
Short-container-title:Chirality

Author:

Lawrence Ross F.,Rettie Allan E.,Eddy A. Craig,Trager William F.

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Pharmacology,Catalysis,Analytical Chemistry

Reference25 articles.

1. Comparison of different forms of liver, kidney, and lung microsomal cytochrome P-450 by immunological inhibition of regio- and stereoselective metabolism of warfarin.

2. Cytochrome P-450 isozyme/isozyme functional interactions and NADPH-cytochrome P-450 reductase concentrations as factors in microsomal metabolism of warfarin

3. Stereoselective and regioselective hydroxylation of warfarin and selective O-dealkylation of phenoxazone ethers in human placenta

4. Substrate probes for the mechanism of aromatic hydroxylation catalyzed by cytochrome P-450: selectively deuterated analogs of warfarin

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