Sensitive and specific LC-ESI-MS/MS method for determination of ZYDPLA1, a novel long-acting dipeptidyl peptidase 4 inhibitor in rat plasma: An application for toxicokinetic study in rats

Author:

Giri Poonam1,Patel Nirmal1,Patel Bharat1,Patel Harilal1,Bahekar Rajesh2,Srinivas Nuggehally R.1ORCID,Patel Pankaj R.12,Desai Ranjit2

Affiliation:

1. Department of Drug Metabolism & Pharmacokinetics, Zydus Research Centre; A Division of Cadila Healthcare Ltd.; Ahmedabad India

2. Department of Medicinal Chemistry, Zydus Research Centre; A Division of Cadila Healthcare Ltd.; Ahmedabad India

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference21 articles.

1. Omarigliptin (MK-3102): A novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes;Biftu;Journal of Medicinal Chemistry,2014

2. Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: A comparative review;Deacon;Diabetes, Obesity and Metabolism,2011

3. DPP-4 inhibitors;Dror;Diabetes Care,2011

4. Repeat analysis and incurred sample reanalysis: Recommendation for best practices and Harmonization from the global bioanalysis consortium Harmonization team;Fluhler;American Association of Pharmaceutical Scientists Journal,2014

5. Long-acting glucagon-like peptide 1 receptor agonists: a review of their efficacy and tolerability;Garber;Diabetes Care,2011

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