Affiliation:
1. Center for Applied Statistics Renmin University of China Beijing China
2. School of Statistics Renmin University of China Beijing China
3. Chengdu Center for Disease Prevention and Control Chengdu China
Abstract
AbstractDisease mapping models have been popularly used to model disease incidence with spatial correlation. In disease mapping models, zero inflation is an important issue, which often occurs in disease incidence datasets with high proportions of zero disease count. It is originated from limited survey coverage or unadvanced testing equipment, which makes some regions have no observed patients. Then excessive zeros recorded in the disease incidence dataset would mess up the true distributions of disease incidence and lead to inaccurate estimates. To address this issue, a zero‐inflated disease mapping model is developed in this work. In this model, a zero‐inflated process using Bernoulli indicators is assumed to characterize whether the zero inflation occurs for each region. For regions without zero inflation, a coherent and generative disease mapping model is applied for mapping the spatially correlated disease incidence. Independent spatial random effects are incorporated in both processes to account for the spatial patterns of zero inflation and disease incidence. External covariates are also considered in both processes to better explain the disease count data. To estimate the model, a Markov chain Monte Carlo algorithm is proposed. We evaluate model performance via a variety of simulation experiments. Finally, a Lyme disease dataset of Virginia is analyzed to illustrate the application of the proposed model.
Funder
Renmin University of China
Ministry of Education of the People's Republic of China
National Natural Science Foundation of China
Subject
Statistics, Probability and Uncertainty,General Medicine,Statistics and Probability
Cited by
1 articles.
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