Application of simplex-based experimental optimization to challenging bioprocess development problems: Case studies in downstream processing-Reference-Cited by-同舟云学术

Application of simplex-based experimental optimization to challenging bioprocess development problems: Case studies in downstream processing

Published:2016-02-29 Issue:2 Volume:32 Page:404-419
ISSN:8756-7938
Container-title:Biotechnology Progress
language:en
Short-container-title:Biotechnol Progress

Author:

Konstantinidis Spyridon¹,Welsh John P.²,Roush David J.²,Velayudhan Ajoy¹

Affiliation:

1. Dept. of Biochemical Engineering; The Advanced Centre for Biochemical Engineering, University College London; Bernard Katz Building, Gordon Street London WC1H 0AH U.K.

2. Process Development and Engineering; Merck & Co. Inc; Kenilworth NJ

Publisher

Wiley

Subject

Biotechnology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/btpr.2234/fullpdf

Reference16 articles.

1. Chromatography process development in the quality by design paradigm I: Establishing a high throughput process development platform as a tool for estimating “characterization space” for an ion exchange chromatography step;Bhambure;Biotechnol Prog.,2013

2. Development of an intermediate chromatography step in an insulin purification process. The use of a High Throughput Process Development approach based on selectivity parameters;Heldin;J Chrom B.,2014

3. High throughput process development in biomanufacturing;Łącki;Curr Opin Chem Eng.,2014

4. A practical strategy for using miniature chromatography columns in a standardized high-throughput workflow for purification development of monoclonal antibodies;Welsh;Biotechnol Prog.,2014

5. The simplex algorithm for the rapid identification of operating conditions during early bioprocess development: case studies in Fab’ precipitation and multimodal chromatography;Chhatre;Biotechnol Bioeng.,2011

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A comprehensive review of Design of experiment (DOE) for water and wastewater treatment application - Key concepts, methodology and contextualized application;Journal of Water Process Engineering;2022-06

2. High-Throughput Process Development for the Chromatographic Purification of Viral Antigens;Vaccine Delivery Technology;2020-09-22

3. Hybrid optimization of preparative chromatography for a ternary monoclonal antibody mixture;Biotechnology Progress;2019-06-25

4. Design of experiments applications in bioprocessing: Chromatography process development using split design of experiments;Biotechnology Progress;2018-11-04

5. Data‐driven multi‐objective optimization via grid compatible simplex technique and desirability approach for challenging high throughput chromatography applications;Biotechnology Progress;2018-10-09