Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid
Author:
Affiliation:
1. Ann Romney Center for Neurologic Diseases, Department of NeurologyBrigham and Women's Hospital and Harvard Medical School Boston MA
2. Genentech (a member of the Roche Group) South San Francisco CA
Funder
Harvard NeuroDiscovery Center
Brigham and Women's Hospital
National Institute on Aging
Publisher
Wiley
Subject
Clinical Neurology,Neurology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/ana.25513
Reference26 articles.
1. The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade
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4. A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid
5. An Effector-Reduced Anti- -Amyloid (A ) Antibody with Unique A Binding Properties Promotes Neuroprotection and Glial Engulfment of A
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