A Novel Osteogenic Oxysterol Compound for Therapeutic Development to Promote Bone Growth: Activation of Hedgehog Signaling and Osteogenesis Through Smoothened Binding

Author:

Montgomery Scott R1,Nargizyan Taya2,Meliton Vicente2,Nachtergaele Sigrid3,Rohatgi Rajat4,Stappenbeck Frank2,Jung Michael E5,Johnson Jared S1,Aghdasi Bayan1,Tian Haijun1,Weintraub Gil1,Inoue Hirokazu1,Atti Elisa6,Tetradis Sotirios6,Pereira Renata C7,Hokugo Akishige8,Alobaidaan Raed1,Tan Yanlin1,Hahn Theodor J9,Wang Jeffrey C10,Parhami Farhad2

Affiliation:

1. Department of Orthopedic Surgery; University of California, Los Angeles (UCLA); Los Angeles CA USA

2. Department of Medicine; David Geffen School of Medicine, UCLA; Los Angeles CA USA

3. Department of Biochemistry; Stanford University School of Medicine; Stanford CA USA

4. Department of Medicine; Stanford University School of Medicine; Stanford CA USA

5. Department of Chemistry and Biochemistry; UCLA; Los Angeles CA USA

6. School of Dentistry; UCLA; Los Angeles CA USA

7. Department of Pediatric Nephrology; UCLA; Los Angeles CA USA

8. Department of Plastic Surgery; UCLA; Los Angeles CA USA

9. Veterans' Administration (VA) Greater Los Angeles Healthcare System and Geriatric Research, Education, and Clinical Center; Los Angeles CA USA

10. Department of Orthopedic Surgery; University of Southern California (USC); Los Angeles CA USA

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

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