Author:
Wang Hui,Qi Li-li,Shema Clement,Jiang Kui-ying,Ren Ping,Wang He,Wang Lei
Abstract
With the development of social population ageing, bone fracture has become a global public health problem due to its high morbidity, disability and mortality. Fracture healing is a complex phenomenon involving the coordinated participation of immigration, differentiation and proliferation of inflammatory cells, angioblasts, fibroblasts, chondroblasts and osteoblasts which synthesize and release bioactive substances of extracellular matrix components, Mortality caused by age-related bone fractures or osteoporosis is steadily increasing worldwide as the population ages. Fibroblasts play an important role in the process of fracture healing. However, it is not clear how the growth factors and extracellular matrix stiffness of the bone-regeneration microenvironment affects the function of osteoblasts and fibroblasts in healing process. Therefore, this article focuses on the role of fibroblasts in the process of fracture healing and mechanisms of research progress.
Reference115 articles.
1. Advances in the application of ultrasound for fracture diagnosis and treatment;Du;Eur Rev Med Pharmacol Sci,2022
2. Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019;Lancet Healthy Longevity,2021
3. Fracture healing in the setting of endocrine diseases, aging, and cellular senescence;Saul;Endocrine Rev,2022
4. Sex-specific differences in fetal germ cell apoptosis induced by ionizing radiation;Guerquin;Hum Reprod (Oxford England),2009
5. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures;Johnell;Osteoporosis Int J established as result cooperation between Eur Foundation Osteoporosis Natl Osteoporosis Foundation USA,2006
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献