Leveraging Human Plasma‐Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Cytochrome P450 3A4 by Modafinil-Reference-Cited by-同舟云学术

Leveraging Human Plasma‐Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Cytochrome P450 3A4 by Modafinil

Published:2021-11-02 Issue:2 Volume:111 Page:425-434
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin Pharma and Therapeutics

Author:

Rodrigues A. David¹,Wood Linda S.²,Vourvahis Manoli³,Rowland Andrew⁴

Affiliation:

1. Absorption, Distribution, Metabolism, and Elimination Sciences, Medicine Design, Worldwide Research & Development Pfizer Inc Groton Connecticut USA

2. Pharmacogenomics, Precision Medicine Worldwide Research & Development Pfizer Inc Groton Connecticut USA

3. Clinical Pharmacology Global Product Development Pfizer Inc New York New York USA

4. College of Medicine and Public Health Flinders University Adelaide South Australia Australia

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2440

Reference52 articles.

1. IN VITRO AND IN VIVO DRUG INTERACTIONS INVOLVING HUMAN CYP3A

2. Center for Drug Evaluation and Research US Food and Drug Administration.Guidance for industry:in vitrodrug interaction studies — cytochrome P450 enzyme‐ and transporter‐mediated drug interactions (January2020).

3. Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach

4. Predicting inductive drug–drug interactions

5. Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data

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