Computational design of novel inhibitors to overcome weed resistance associated with acetohydroxyacid synthase (AHAS) P197L mutant

Author:

Qu Ren-Yu1,Yang Jing-Fang1,Liu Yu-Chao1,Chen Qiong1,Hao Ge-Fei1,Niu Cong-Wei2,Xi Zhen23,Yang Guang-Fu13

Affiliation:

1. Key Laboratory of Pesticide and Chemical Biology of Ministry of Education; College of Chemistry, Central China Normal University; Wuhan 430079 People's Republic of China

2. State Key Laboratory of Elemento-Organic Chemistry; Nankai University; Tianjin 300071 People's Republic of China

3. Collaborative Innovation Center of Chemical Science and Engineering; Tianjing 300071 People's Republic of China

Funder

National Key Technologies R&D Program

National Natural Science Foundation of China

Publisher

Wiley

Subject

Insect Science,Agronomy and Crop Science,General Medicine

Reference41 articles.

1. Binding and activation of thiamin diphosphate in acetohydroxyacid synthase;Bar-Ilan;Biochemistry,2001

2. Acetohydroxyacid synthase;Duggleby;J Biochem Mol Biol,2000

3. Biosynthesis of branched-chain amino-acids from test-tube to field;Singh;Plant Cell,1995

4. Computational determination of fundamental pathway and activation barriers for acetohydroxyacid synthase-catalyzed condensation reactions of alpha-keto acids;Xiong;J Comput Chem,2010

5. Functional evaluation of residues in the herbicide-binding site of Mycobacterium tuberculosis acetohydroxyacid synthase by site-directed mutagenesis;Jung;Enzyme Microb Technol,2015

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