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Functional evaluation of residues in the herbicide-binding site of Mycobacterium tuberculosis acetohydroxyacid synthase by site-directed mutagenesis

  • Published:2015-10 Issue: Volume:78 Page:18-26
  • ISSN:0141-0229
  • Container-title:Enzyme and Microbial Technology
  • language:en
  • Short-container-title:Enzyme and Microbial Technology

Author:

Jung In-Pil,Cho Jun-Haeng,Koo Bon-Sung,Yoon Moon-Young

Funder

Cooperative Research Program for Agriculture Science & Technology Development

Publisher

Elsevier BV

Subject

Applied Microbiology and Biotechnology,Biochemistry,Biotechnology,Bioengineering

Reference23 articles.

1. Global tuberculosis incidence and mortality during 1990–2000;Dolin;Bull. World Health Organ.,1994

2. Treatment outcomes and long-term survival in patients with extensively drug-resistant tuberculosis;Kim;Am. J. Respir. Crit. Care Med.,2008

3. Advances in the development of new tuberculosis drugs and treatment regimens;Zumla;Nat. Rev. Drug Discov.,2013

4. Acetohydroxyacid synthase: a target for antimicrobial drug discovery;Pue;Curr. Pharm. Des.,2014

5. Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages;Bange;Infect. Immun.,1996

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