A novel thiophene‐3‐carboxamide analog of annonaceous acetogenin exhibits antitumor activity via inhibition of mitochondrial complex I
Author:
Affiliation:
1. Molecular Pharmacology Cancer Chemotherapy Center Japanese Foundation for Cancer Research Tokyo Japan
2. Pharmaceutical Manufacturing Chemistry Kyoto Pharmaceutical University Kyoto Japan
Funder
Japan Society for the Promotion of Science
Publisher
Wiley
Subject
General Pharmacology, Toxicology and Pharmaceutics,Neurology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.246
Reference51 articles.
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3. Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe
4. Cells depleted of mitochondrial DNA (p0) yield insight into physiological mechanisms
5. Studies on the Acetogenins of Formosan Annonaceous Plants, II. Cytotoxic Acetogenins from Annona reticulata
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